Thyrotropin-releasing hormone precursor—A novel marker of the mouse definitive endoderm
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منابع مشابه
The Therapeutic Effect of Thyrotropin Releasing Hormone in Amyotrophic Sclerosis
Although the issue has not yet been fully resolved, there is reason to believe that TRI-I may have a trophic effect on the normal motoneuron and may transien tly improve the neurologic deficit in ALS. Since ALS is not a simple TRI-I deficiency disease, this improvement probably occurs via a secondary mecha -nism-possibly another neurotransmitter. It is uncertain at this time whether this effec...
متن کاملIdentification of the thyrotropin-releasing-hormone-degrading
A time-dependent inhibition of the thyrotropin-releasing-hormone (TRH)-degrading ectoenzyme (EC 3.4.19.-) from rat brain by the metal-complexing agents imidazole, NaCN, EDTA and 1,10-phenanthroline could be demonstrated. In contrast, the inhibition by the non-chelating analogues 4,7and 1,7-phenanthroline was not time-dependent. At a concentration of 100 ,M EDTA the enzymic activity decreased by...
متن کاملAssessment of thyrotropin-releasing hormone and thyrotropin reserve in man.
Endogenous thyrotropin-releasing hormone (TRH) reserve and pituitary thyrotropin (TSH) reserve were assessed in four normal subjects, three patients post-cryohypophysectomy, one patient with a hypothalamic lesion secondary to trauma, and four patients with Sheehan's syndrome. TSH reserve was determined by the immunoassayable TSH response to 500 mug TRH given i.v. (TRH stimulation test). TRH res...
متن کاملCardiovascular pharmacology of thyrotropin releasing hormone.
Thyrotropin releasing hormone (TRH) and its receptors are present in the cardiovascular nuclei of the brain as well as in the intermediolateral cell column of spinal cord. Anatomical, neurophysiological, functional and pharmacological studies suggest that TRH is a neurotransmitter/neuromodulator in the central nervous system. Administration of TRH to experimental animals or human subjects induc...
متن کاملThyrotropin Releasing Hormone Stimulation of Prolactin Release
Thyrotropin releasing hormone (TRH) and high extracellular K+ induce prolactin release from rat pituitary cells (GH3 cells) in culture. TRH, as well as high K' (SO m), was shown to increase 46Ca2' efflux from these cells. The effects of TRH and high K' on membrane polarization was determined indirectly using the lipophilic cation, triphenylmethyl phosphonium ion (TPMP'). The resting membran...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2007
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2007.03.609